Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study

Reddon, H and Gerstein, H C and Engert, J C and Mohan, V and Bosch, J and Desai, D and Bailey, S D and Diaz, R and Yusuf, S and Anand, S S and Meyre, D (2016) Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study. Scientific Reports, 6 . p. 18672. ISSN 2045-2322



Physical activity (PA) has been shown to reduce the impact of FTO variation and obesity genetic risk scores (GRS) on BMI. We examined this interaction using a quantitative measure of PA and two adiposity indexes in a longitudinal multi-ethnic study. We analyzed the impact of PA on the association between 14 obesity predisposing variants (analyzed independently and as a GRS) and baseline/follow-up obesity measures in the multi-ethnic prospective cohort EpiDREAM (17423 participants from six ethnic groups). PA was analyzed using basic (low-moderate-high) and quantitative measures (metabolic equivalents (METS)), while BMI and the body adiposity index (BAI) were used to measure obesity. Increased PA was associated with decreased BMI/BAI at baseline/follow-up. FTO rs1421085, CDKAL1 rs2206734, TNNl3K rs1514176, GIPR rs11671664 and the GRS were associated with obesity measures at baseline and/or follow-up. Risk alleles of three SNPs displayed nominal associations with increased (NTRK2 rs1211166, BDNF rs1401635) or decreased (NPC1 rs1805081) basic PA score independently of BMI/BAI. Both basic and quantitative PA measures attenuated the association between FTO rs1421085 risk allele and BMI/BAI at baseline and follow-up. Our results show that physical activity can blunt the genetic effect of FTO rs1421085 on adiposity by 36-75% in a longitudinal multi-ethnic cohort.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:BMI; Physical activity
Subjects:Nutrition and Diabetes
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:966
Deposited By:surendar radha
Deposited On:25 Feb 2016 11:52
Last Modified:25 Feb 2016 11:52

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