Postprandial glycaemic excursions and cardiovascular risk.

Abstract

During the last few years there is increasing recognition regarding the role of postprandial hyperglycaemia (PPHG) in contributing to the development of micro- and macrovascular complications of diabetes. PPHG has a harmful effect on the vascular endothelium, which is mainly mediated by oxidative stress. Numerous epidemiological and longitudinal studies have shown elevated PPHG to be an independent risk factor for cardiovascular disease and increased mortality risk. In addition, PPHG contributes significantly to glycosylated haemoglobin levels particularly in relatively well controlled type 2 diabetic subjects. PPHG is thus emerging as a valid therapeutic target to minimise cardiovascular disease risk. This review looks at the association of postprandial excursions and the risk for cardiovascular disease.