Radhika, G and Ganesan, A and Sathya, R M and Sudha, V and Mohan, V (2009) Dietary carbohydrates, glycemic load and serum high-density lipoprotein cholesterol concentrations among South Indian adults. European Journal of Clinical Nutrition, 63 (3). pp. 413-420.
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To examine the relationship between dietary carbohydrates, glycemic load and high-density lipoprotein cholesterol (HDL-C) concentrations in Asian Indians, a high-risk group for diabetes and premature coronary artery disease. Subjects/methods: The study population comprised of 2043 individuals aged X20 years randomly selected from Chennai Urban Rural Epidemiological Study (CURES), an ongoing population-based study on a representative population of Chennai (formerly Madras) city in southern India. Participants with self-reported history of diabetes or heart disease or on drug therapy for dyslipidemia were excluded from the study. Dietary carbohydrates, glycemic index and glycemic load were assessed using a validated interviewer administered semiquantitative Food Frequency Questionnaire (FFQ). Results: Both dietary glycemic load (Po0.0001) and total dietary carbohydrate intake (Po0.001) were significantly associated with higher serum triglyceride levels and lower serum HDL-C levels. For the lowest to highest quintile of glycemic load, the multivariate-adjusted mean HDL-C values were 44.1mg per 100 ml and 41.2mg per 100 ml (6.6% difference, P for trendo0.001), while for total carbohydrate it was less (5% difference, P for trend¼0.016). The pattern of decrease in HDL-C for the lowest to highest quintile of glycemic load was more pronounced among men (1st vs 5th quintile: adjusted HDL-C: 4.3mg per 100 ml decrease (10.3%)) than women (1st vs 5th quintile: adjusted HDL-C: 3.2mg per 100 ml decrease (6.9%)). Our findings indicate that both total carbohydrates and dietary glycemic load intake are inversely associated with plasma HDL-C concentrations among Asian Indians, with dietary glycemic load having a stronger association.
|Uncontrolled Keywords:||carbohydrates; glycemic load; glycemic index; HDL-cholesterol; Asian Indians; South Asians|
|Subjects:||Diabetes > Diabetes in India|
Nutrition and Diabetes
|Divisions:||Department of Nutrition and Dietitics|
|Deposited By:||INVALID USER|
|Deposited On:||28 Sep 2009 21:04|
|Last Modified:||29 Sep 2009 10:42|
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