Absence of Association of Metabolic Syndrome with PPARGC1A, PPARG and UCP1 Gene Polymorphisms in Asian Indians

Vimaleswaran, K S and Radha, V and Deepa, R and Mohan, V (2007) Absence of Association of Metabolic Syndrome with PPARGC1A, PPARG and UCP1 Gene Polymorphisms in Asian Indians. Metabolic Syndrome and Related Disorders, 5 (2). pp. 153-62. ISSN 1540-4196

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The objective of this study was to evaluate the association of PPARG coactivator1 alpha (PPARGC1A), peroxisome proliferator activated receptor gamma (PPARG), and uncoupling protein1 (UCP1) gene polymorphisms with the metabolic syndrome (MS) in an Asian Indian population. Nine common polymorphisms were genotyped via polymerase chain reaction restriction fragment length polymorphism and direct sequencing in 950 normal glucose-tolerant subjects and 550 type 2 diabetic subjects, chosen randomly from the Chennai Urban Rural Epidemiological Study, an ongoing population based study in Southern India. Among the 9 polymorphisms examined, only the Thr394Thr variant of the PPARGC1A gene was significantly associated with diabetes and obesity. The genotype frequency of GA of Thr394Thr variant was 16% (138/887) in the nonMS group and 22% (136/613) in the MS group, and this genotype frequency was significantly higher with MS both in males (p 0.01) and females (p 0.05), compared to the without-MS group. Logistic regression analysis revealed that the odds ratio for MS for the susceptible genotype GA of Thr394Thr was 1.411 [95% CI: 1.03–1.84, p 0.012]. In the multiple logistic regression analysis, however, there was no association of this polymorphism as an independent factor with MS. Hence, the study shows that the polymorphisms in the PPARGC1A, PPARG and UCP1 genes are not associated with MS in Asian Indians.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.1089/met.2006.0032
Uncontrolled Keywords:Metabolic Syndrome;Gene Polymorphisms ;Asian Indians;UCP1,PPARGC1A;PPARG
Subjects:Diabetes > CURES
Genetics and Diabetes > Genetic Risk Factors
Diabetes > Metabolic Syndrome
Divisions:Neonatal Diabetes
Department of Diabetology
ID Code:96
Deposited On:24 Oct 2009 09:16
Last Modified:24 Oct 2009 09:16

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