Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians

Gokulakrishnan, K and Manokaran, K and Pandey, G K and Amutha, A and Ranjani, H and Anjana, R M and Mohan, V (2015) Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians. Diabetes Research and Clinical Practice, 109 (1). p. 71. ISSN 01688227

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Background and Aims: Betatrophin is emerging as a marker for compensatory beta cell proliferation. While betatrophin has been mainly investigated in adults, there is a lack of data on betatrophin levels in youth-onset type 2 diabetes mellitus (T2DM-Y). The aim of this study was to determine levels of betatrophin and its association with T2DM-Y in Asian Indian participants. Methods: We recruited 100 individuals with normal glucose tolerance (NGT; n = 50) and newly-diagnosed cases (within 18 months of first diagnosis) of T2DM-Y (n = 50) with onset between 12 and 24 years of age from a large tertiary diabetes center in Chennai in southern India. Insulin resistance was measured by homeostatic model (HOMA-IR) and insulin secretion by oral disposition index (DIO). Betatrophin levels were measured by enzymelinked immunosorbent assay. Results: Betatrophin levels were significantly lower in the T2DM-Y group compared with the NGT group (803 vs 1104 pg/ml, p < 0.001). Betatrophin showed a significant inverse correlation with waist circumference ( p = 0.035), HOMA-IR ( p < 0.001), fasting and 2 h postprandial glucose ( p < 0.01), glycated hemoglobin ( p = 0.019) and a positive correlation with fasting Cpeptide ( p < 0.001) and DIO ( p = 0.012). In regression analysis, betatrophin was independently associated with T2DM-Y even after adjustment for age, gender, and waist circumference (OR per standard deviation: 0.562, 95% CI: 0.342–0.899, p = 0.019). However, the association was lost when HOMA-IR was included in the model (OR: 1.141, 95% CI: 0.574– 2.249; p = 0.646). Conclusion: Betatrophin levels are lower in T2DM-Y and this association is likely mediated through insulin resistance.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Betatrophin; Insulin resistance; Type 2 diabetes; Asians Indians
Subjects:Diabetes > Diabetes in India
Diabetology > Diabetes Mellitus Type 2
Biochemistry,Cell and Molecular Signalling
Divisions:Department of Cell and Molecular Biology
Department of Diabetology
Department of Advanced Research Biochemistry
ID Code:927
Deposited By:surendar radha
Deposited On:24 Jul 2015 12:45
Last Modified:24 Jul 2015 12:45

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