Identification of Genetic Variants of Gestational Diabetes in South Indians

Kanthimathi, S and Chidambaram, M and Liju, S and Bhavadharini, B and Bodhini, D and Prakash, V G and Amutha, A and Bhavatharini, A and Anjana, R M and Mohan, V and Radha, V (2015) Identification of Genetic Variants of Gestational Diabetes in South Indians. Diabetes Technology & Therapeutics, 17 (7). p. 462. ISSN 1520-9156

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Background: This study examined the association in a South Indian population with gestational diabetes mellitus (GDM) of type 2 diabetes risk variants that have previously conferred susceptibility to GDM in other populations. Subjects and Methods: The study groups comprised 518 women with GDM and 910 pregnant women with normal glucose tolerance (NGT). Women with GDM were recruited from a tertiary diabetes center in Chennai, in south India, and NGT women were selected from antenatal clinics also in Chennai. Genomic DNA was isolated from whole blood using the phenol chloroform method. Twelve previously reported GDM-associated single nucleotide polymorphisms (SNPs) in or near nine loci were genotyped using the MassARRAY system (Sequenom, San Diego, CA). Results: Among the 12 SNPs genotyped, 11 SNPs were in Hardy–Weinberg equilibrium and had a call rate of > 95%. Of the 11 SNPs previously associated with GDM in other populations, significant association was observed only with the rs7754840 and rs7756992 SNPs of the CDK5 regulatory subunit associated protein 1- like 1 (CDKAL1) gene in this population. The minor alleles of the SNPs rs7754840 and rs7756992 showed significant susceptibility to GDM with an odds ratio of 1.34 (95% confidence interval, 1.12–1.60; P = 0.0013) and 1.45 (95% confidence interval, 1.21–1.72; P = 0.00004), respectively. Conclusions: The rs7754840 and rs7756992 SNPs of the CDKAL1 gene were found to be associated with GDM in this south Indian population. This is the first study describing genetic susceptibility of GDM in Asian Indians.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Genetic variants ; Gestational Diabetes; South Indian
Subjects:Diabetes Epidemiology
Genetics and Diabetes
Divisions:Department of Epidemiology
Department of Cell and Molecular Biology
Department of Diabetology
ID Code:915
Deposited By:surendar radha
Deposited On:06 Jul 2015 12:34
Last Modified:06 Jul 2015 12:34

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