Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes

Adaikalakoteswari, A and Jayashri, R and Sukumar, N and Venkataraman, H and Pradeepa, R and Gokulakrishnan, K and Anjana, R M and McTernan, P G and Tripathi, G and Patel, V and Kumar, S and Mohan, V and Saravanan, P (2014) Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology, 13 (1). p. 129. ISSN 1475-2840



BACKGROUND: Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India. METHODS: Type 2 diabetes patients from two secondary care diabetic centres (Europeans - UK and Indians - India) were studied. Serum vitamin B12, folate and biochemical parameters were measured. RESULTS: The prevalence rates of vitamin B12 deficiency (<191 ng/L) were 27% and 12% in Europeans and Indians, respectively and higher in metformin treated type 2 diabetes patients. In linear regression analysis, after adjusting for all likely confounding factors, vitamin B12 independently associated with triglycerides in both the populations and cholesterol/HDL ratio in Indians. Logistic regression showed type 2 diabetes patients with vitamin B12 deficiency were at significantly higher odds of having coexisting coronary artery disease (CAD) in Europeans with similar but non-significant trend in Indians, after adjusting for all likely confounding factors. CONCLUSIONS: The prevalence of vitamin B12 deficiency is common in type 2 diabetes patients and is associated with adverse lipid parameters. Type 2 diabetes management guidelines should include the recommendation for regular testing for B12 levels, especially for those on metformin.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Vitamin B12, Type 2 Diabetes, Lipid
Subjects:Diabetes Epidemiology
Biochemistry,Cell and Molecular Signalling
Divisions:Department of Epidemiology
Department of Diabetology
Department of Advanced Research Biochemistry
ID Code:886
Deposited By:surendar radha
Deposited On:22 Dec 2014 12:00
Last Modified:22 Dec 2014 12:00

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