‘ADOPT’ and ‘DREAM’ trials and the Indian perspective

Mohan, V and Sandeep, S (2007) ‘ADOPT’ and ‘DREAM’ trials and the Indian perspective. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 1 (3). pp. 189-92. ISSN 18714021

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Two recent landmark studies, the ADOPTand DREAM trials have looked at efficacy of rosiglitazone in the treatment and prevention of type 2 diabetes. The results of the ADOPTstudy done on recently diagnosed type 2 diabetic subjects suggested that rosiglitazone was more effective in slowing down the progression to monotherapy failure compared to metformin or glyburide. However, rosiglitazone was associated with weight gain, edema, increase in the levels of LDL cholesterol and a reduction in the haematocrit and higher rates of fractures in women. The DREAM study looked at the efficacy of rosiglitazone in the prevention of type 2 diabetes in individuals with prediabetes. There was a 62% reduction in risk for developing diabetes with rosiglitazone and this effectwasmore pronounced in obese and overweight individuals. Liver function was unaffected or improved with rosiglitazone. However, the frequency of non-fatal heart failure was higher in the rosiglitazone, groupcompared to the placebo, group. The prevalence of type 2 diabetes in India has been steadily increasing over the decades and the prevalence of Impaired Glucose Tolerance (IGT) is also very high. Although the ADPOT and DREAM have widened the horizon for the use of rosiglitazone in both treatment and prevention of type 2 diabetes, the side-effects associated with it points to the need for carefully choosing patients.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.1016/j.dsx.2007.06.003
Uncontrolled Keywords:ADOPT;DREAM;Indian perspective
Subjects:Diabetes Clinical Trials > Randomized Trial
Diabetology > Diabetes Reproductive Health
Divisions:Department of Diabetology
Department of Clinical Trials
ID Code:88
Deposited On:22 Oct 2009 11:05
Last Modified:22 Oct 2009 11:05
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