Noninvasive Type 2 Diabetes Screening: Clinical Evaluation of SCOUT DS in an Asian Indian Cohort

Mohan, V and Rani, CS Shanthi and Regin, B S and Balasubramanyam, M and Anjana, R M and Matter, N I and Poongothai, S and Deepa, M and Pradeepa, R (2013) Noninvasive Type 2 Diabetes Screening: Clinical Evaluation of SCOUT DS in an Asian Indian Cohort. Diabetes Technology & Therapeutics, 15 (1). p. 39. ISSN 1520-9156

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Objective: This study evaluated the noninvasive, point-of-care diabetes screening device, Scout DS (VeraLight Inc., Albuquerque, NM) (SCOUT), in a native Asian Indian cohort. Research Design and Methods: SCOUT is a tabletop, skin fluorescence spectrometer that reports a risk score following a 3–4-min noninvasive measurement of a subject’s left volar forearm. SCOUT, fasting plasma glucose (FPG), and hemoglobin A1c (A1C) were compared for detection of abnormal glucose tolerance (AGT) in a cohort of 256 subjects without previous diagnosis of diabetes or impaired glucose tolerance in Chennai, India. After an overnight fast, a 75-g, 2-h oral glucose tolerance test was administered, and AGT was defined as a plasma glucose value ‡ 140mg/dL (7.8mmol/dL). Sensitivity, false-positive rate (FPR), and receiver-operating characteristics area under the curve for AGT detection were computed for SCOUT, FPG, and A1C. Intra-day reproducibility of SCOUT was assessed. Results: SCOUT, FPG, and A1C (at respective thresholds of 50, 110 mg/dL, and 5.7%) exhibited sensitivities of 87%, 32%, and 86%, respectively, and FPR of 52%, 3%, and 58%, respectively. For the 177 subjects receiving a valid SCOUT Diabetes Score on both measurement attempts, the coefficient of variation was 5.8%, and the Pearson correlation was 0.91. A SCOUT score could be obtained on 91% of subjects after two attempts. Conclusions: The performance of SCOUT is similar to that of A1C, whereas FPG had a much lower sensitivity. SCOUT is an effective tool for AGT screening in Asian Indians.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:SCOUT DS; Type 2 Diabets; Asian Indian Cohort
Subjects:Diabetes Epidemiology
Diabetology > Diabetes Mellitus Type 2
Divisions:Department of Epidemiology
Department of Diabetology
Department of Clinical Trials
ID Code:863
Deposited By:surendar radha
Deposited On:06 Nov 2014 12:25
Last Modified:06 Nov 2014 12:25

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