HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis

Soulimane, S and Simon, D and Herman, W H and Langenberg, C and Lee, C M Y and Colagiuri, S and Shaw, J E and Zimmet, P Z and Magliano, D and Ferreira, S R G and Dong, Y and Zhang, Lei and Jorgensen, T and Tuomilehto, J and Mohan, V and Christensen, D L. and Kaduka, L and Dekker, J M and Nijpels, G and Stehouwer, C D A and Lantieri, O and Fujimoto, W Y and Leonetti, D L. and McNeely, M J and Borch-Johnsen, K and Boyko, E J and Vistisen, D and Balkau, B (2014) HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis. Diabetologia, 57 (1). p. 30. ISSN 0012-186X



Aims/Hypothesis The relationships between smoking and glycaemic variables have not been well explored. We compared HbA1c, fasting plasma glucose (FPG) and 2 h plasma glucose (2H-PG) in current, ex- and never-smokers. Methods This meta-analysis used individual data from16,886 men and 18,539 women without known diabetes in 12 DETECT-2 consortium studies and in the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) and Telecom studies. Means of three glycaemic variables in current, ex- and never-smokers were modelled by linear regression, with study as a random factor. The I 2 statistic was used to evaluate heterogeneity among studies. Results HbA1c was 0.10% (95% CI 0.08, 0.12) (1.1 mmol/mol [0.9, 1.3]) higher in current smokers and 0.03% (0.01, 0.05) (0.3 mmol/mol [0.1, 0.5]) higher in ex-smokers, compared with never-smokers. For FPG, there was no significant difference between current and never-smokers (−0.004 mmol/l [−0.03, 0.02]) but FPG was higher in ex-smokers (0.12 mmol/l [0.09, 0.14]). In comparison with never-smokers, 2H-PG was lower (−0.44 mmol/l [−0.52, −0.37]) in current smokers, with no difference for exsmokers (0.02 mmol/l [−0.06, 0.09]). There was a large and unexplained heterogeneity among studies, with I 2 always above 50%; I 2 was little changed after stratification by sex and adjustment for age and BMI. In this study population, current smokers had a prevalence of diabetes that was 1.30% higher as screened by HbA1c and 0.52% lower as screened by 2H-PG, in comparison with never-smokers. Conclusion/interpretation Across this heterogeneous group of studies, current smokers had a higher HbA1c and lower 2H-PG than never-smokers. This will affect the chances of smokers being diagnosed with diabetes.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.1007/s00125-013-3058-y
Uncontrolled Keywords:FPG, HbA1c, 2H-PG, Meta-analysis, Smoking
Subjects:Diabetes > Diabetes Risk Factors
Diabetes > Diabetes in India
Diabetes > Diabetes Research
Divisions:Department of Epidemiology
Department of Diabetology
Department of Clinical Trials
ID Code:829
Deposited By:surendar radha
Deposited On:04 Aug 2014 16:46
Last Modified:04 Aug 2014 16:46

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