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Xiao Ou and Shuldiner, Alan R and Sigurðsson, Gunnar and Sijbrands, Eric and Silveira, Angela and Sim, Xueling and Sivapalaratnam, Suthesh and Small, Kerrin S and So, Wing Yee and Stančáková, Alena and Stefansson, Kari and Steinbach, Gerald and Steinthorsdottir, Valgerdur and Stirrups, Kathleen and Strawbridge, Rona J and Stringham, Heather M and Sun, Qi and Suo, Chen and Syvänen, Ann-Christine and Takayanagi, Ryoichi and Takeuchi, Fumihiko and Tay, Wan Ting and Teslovich, Tanya M and Thorand, Barbara and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Tikkanen, Emmi and Trakalo, Joseph and Tremoli, Elena and Trip, Mieke D and Tsai, Fuu Jen and Tuomi, Tiinamaija and Tuomilehto, Jaakko and Uitterlinden, Andre G and Valladares-Salgado, Adan and Vedantam, Sailaja and Veglia, Fabrizio and Voight, Benjamin F and Wang, Congrong and Wareham, Nicholas J and Wennauer, Roman and Wickremasinghe, Ananda R and Wilsgaard, Tom and Wilson, James F and Wiltshire, Steven and Winckler, Wendy and Wong, Tien Yin and Wood, Andrew R and Wu, Jer-Yuarn and Wu, Ying and Yamamoto, Ken and Yamauchi, Toshimasa and Yang, Mingyu and Yengo, Loic and Yokota, Mitsuhiro and Young, Robin and Zabaneh, Delilah and Zhang, Fan and Zhang, Rong and Zheng, Wei and Zimmet, Paul Z and Altshuler, David and Bowden, Donald W and Cho, Yoon Shin and Cox, Nancy J and Cruz, Miguel and Hanis, Craig L and Kooner, Jaspal and Lee, Jong-Young and Seielstad, Mark and Teo, Yik Ying and Boehnke, Michael and Parra, Esteban J and Chambers, John C and Tai, E Shyong and McCarthy, Mark I and Morris, Andrew P (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3). p. 234. ISSN 1061-4036
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Abstract
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
Item Type: | Article |
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Official URL/DOI: | http://dx.doi.org/10.1038/ng.2897 |
Uncontrolled Keywords: | Genome, Architecture, T2D |
Subjects: | Diabetes Epidemiology Genetics and Diabetes |
Divisions: | Department of Epidemiology Department of Diabetology |
ID Code: | 827 |
Deposited By: | surendar radha |
Deposited On: | 25 Jul 2014 13:18 |
Last Modified: | 25 Jul 2014 13:18 |
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