Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset Type 1 and Type 2 Diabetes

Rajalakshmi, R and Amutha, A and Ranjani, H and Ali, M K and Unnikrishnan, R and Anjana, R M and Narayan, K M V and Mohan, V (2014) Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset Type 1 and Type 2 Diabetes. Journal of Diabetes and its Complications, 28 (3). p. 291. ISSN 10568727

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Aim: To assess the prevalence and risk factors for diabetic retinopathy (DR) in people with young onset type 1 (T1DM-Y) and type 2 diabetes (T2DM-Y). Methods: T1DM-Y(n = 150) and T2DM-Y(n = 150) participants, age between 10 and 25 years at diagnosis, had a complete clinical evaluation, biochemical assessment, and four field digital retinal colour photography. The Early Treatment Diabetic Retinopathy Study grading system was used to grade DR. Proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME) were considered as sight threatening DR. Results: The prevalence of any DR was 53.3% [95% CI 45.3–61.3] in T1DM-Y (duration of diabetes: 12.4 ± 7.4years) and 52.7% [44.7–60.7] in T2DM-Y (11.8 ± 8.3 years). The age and gender adjusted prevalence of DR, DME and PDRwas 62.5%, 10% and 7.3% in T1DM-Y,whereas itwas 65.8%,12.7% and 9.3% in T2DM-Y respectively. In multivariable logistic regression, diabetes duration [Odds ratio (OR) 1.99 per 5 years; CI 1.42–2.79], waist circumference [1.28 per 5 cm;1.05–1.56] and microalbuminuria [2.39 per 50 μg;1.07–5.31]were associatedwith DR in T1DM-Y, and diabetes duration [2.21 per 5 years; 1.61–3.02], diastolic blood pressure [1.54 per 5 mmHg;1.18–2.02], Glycated hemoglobin [1.37 per %;1.07–1.75] and lower stimulated C-peptide [1.54 per 0.5 pmol/ml;1.15–2.05;] were associated with DR in T2DM-Y. Conclusion: Over half of the people with young-onset diabetes, regardless of type, have retinopathy within 10–12 years of diabetes duration, emphasizing the need for regular eye screening and aggressive control of glucose and blood pressure to prevent DR.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Diabetic retinopathy, T1DM-Y, T2DM-Y, Prevalence, Risk factors, Asian Indians
Subjects:Diabetology > Retino Diabetology
Diabetes Epidemiology
Divisions:Department of Opthalmology
Department of Diabetology
ID Code:825
Deposited By:surendar radha
Deposited On:25 Jul 2014 13:05
Last Modified:25 Jul 2014 13:05

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