Advanced glycation index and its association with severity of diabetic retinopathy in type 2 diabetic subjects.

Anitha, B and Sampathkumar, R and Balasubramanyam, M and Rema, M (2008) Advanced glycation index and its association with severity of diabetic retinopathy in type 2 diabetic subjects. Journal of diabetes and its complications, 22 (4). pp. 261-6. ISSN 1873-460X

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Abstract

BACKGROUND: This study investigates the association of advanced glycation index (AGI), a simple assay to detect advanced glycation endproducts (AGEs) in serum, with severity of diabetic retinopathy (DR) in type 2 diabetic subjects. METHODS: The study included 188 type 2 diabetic subjects without DR, 153 subjects with nonproliferative DR, 41 subjects with proliferative DR, and 188 control participants. Serum levels of AGEs were monitored with a spectrofluorimeter by recording Maillard-specific fluorescence. RESULTS: AGI values increased with severity of DR (analysis of variance, P<.0001). Among diabetic subjects, AGI (mean+/-S.E.) was higher among subjects with nonproliferative diabetic retinopathy (NPDR; 6.7+/-0.1 U) and proliferative diabetic retinopathy (PDR; 9.1+/-0.3 U) than among subjects without DR (P<.0001). By arranging the levels of serum AGI in quartiles, the proportion of PDR subjects increased with increasing AGI values, with maximum subjects in the last quartile (trend chi(2)=60.239, P<.0001). AGI was associated with NPDR even after adjusting for age, gender, duration of diabetes, and glycated hemoglobin [odds ratio (OR)=1.33; 95% confidence interval (95% CI)=1.12-1.57; P=.001]. Similarly, AGI showed a significant association with PDR even after adjusting for various risk factors (OR=2.47; 95% CI=1.75-3.47; P<.0001). Receiver-operating-characteristics curve analysis revealed that the threshold level of 8.07 U had a 78% sensitivity, an 83.6% specificity, and an 86.1% accuracy for detecting PDR. CONCLUSION: AGI showed a significant association with the severity of DR and, hence, could be used as a prognostic tool to predict the development and progression of DR.

Item Type:Article
Official URL/DOI:http://www.jdcjournal.com
Uncontrolled Keywords:glycation index;diabetic retinopathy;type 2 diabetic
Subjects:Genetics and Diabetes > Genetic Risk Factors
Diabetology > Retino Diabetology
Divisions:Department of Opthalmology
Neonatal Diabetes
ID Code:80
Deposited By:INVALID USER
Deposited On:21 Oct 2009 15:39
Last Modified:21 Oct 2009 15:39

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