Prevalence and risk factors for diabetic neuropathy in an urban south Indian population: the Chennai Urban Rural Epidemiology Study (CURES-55)

Pradeepa, R and Rema, M and Vignesh, J P and Deepa, M and Deepa, R and Mohan, V (2008) Prevalence and risk factors for diabetic neuropathy in an urban south Indian population: the Chennai Urban Rural Epidemiology Study (CURES-55). Diabetic Medicine, 25 (4). pp. 407-12. ISSN 0742-3071

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Aims This study was conducted to determine the prevalence of, and risk factors for, diabetic neuropathy (DN) in south Indian Type 2 diabetic subjects. Methods Subjects were recruited from the Chennai Urban Rural Epidemiology Study, conducted on a representative cohort from Chennai city. A total of 1629 diabetic subjects were included, of whom 1291 were known to have diabetes (KD) subjects and 338 were randomly selected newly detected diabetic (NDD) subjects. Neuropathy was diagnosed if vibratory perception threshold at the great toe, measured by biothesiometry, exceeded mean + 2 SD of a healthy non-diabetic study population aged 20–45 years (cut point ≥ 20 V). Results The overall prevalence of DN was 26.1% (age-adjusted 13.1%) with no significant difference in gender. The prevalence of neuropathy was significantly higher in KD subjects compared with NDD subjects (27.8 vs. 19.5%, P = 0.002). The prevalence of diabetic retinopathy (24.1 vs. 15.3%, P < 0.0001) and hypertension (51.1 vs. 40.0%, P < 0.0001) were higher in those with neuropathy compared with those without. The odds ratio for neuropathy in subjects with duration of diabetes > 15 years compared with ≤ 5 years was 5.7 (95% confidence interval: 3.52–9.08, P < 0.0001). Regression analysis showed age ( P < 0.0001), glycated haemoglobin ( P = 0.001) and duration of diabetes ( P = 0.045) to be significantly associated with neuropathy. Conclusions This cross-sectional population-based study shows that, among urban south Indian Type 2 diabetic subjects, the prevalence of DN is 26.1% and that DN is significantly associated with age, glycated haemoglobin and duration of diabetes. Diabet. Med. 25, 407–412 (2008) Keywords Asian Indians, diabetes, neuropathy, prevalence, risk factors Abbreviations BMI, body mass index; CI, confidence interval; CURES, Chennai Urban Rural Epidemiology Study; DN, diabetic neuropathy; DR, diabetic retinopathy; FPG, fasting plasma glucose; HbA 1c , glycated haemoglobin; KD, known diabetic; NDD, newly detected diabetic; NPDR, non-proliferative diabetic retinopathy; OGTT, oral glucose tolerance test; OR, odds ratio; PDR, proliferative diabetic retinopathy; SBP, systolic blood pressure; VPT, vibratory perception threshold

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:diabetic neuropathy;CURES-55;Epidemiology Study
Subjects:Diabetology > Neuro Diabetology
Diabetes Epidemiology
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:74
Deposited On:21 Oct 2009 12:02
Last Modified:21 Oct 2009 12:02

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