The Prevalence of Presarcopenia in Asian Indian Individuals With and Without Type 2 Diabetes

Anbalagan, V P and Venkataraman, V and Pradeepa, R and Deepa, M and Anjana, R M and Mohan, V (2013) The Prevalence of Presarcopenia in Asian Indian Individuals With and Without Type 2 Diabetes. Diabetes Technology & Therapeutics, 15 (9). p. 768. ISSN 1520-9156

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Objective: This study compared the skeletal muscle mass and prevalence of presarcopenia between Asian Indian individuals with and without type 2 diabetes. Subjects and Methods: Participants with type 2 diabetes (n = 76) and age- and sex-matched controls without diabetes (n = 76) were drawn from the Chennai Urban Rural Epidemiological Study (CURES), which was carried out on a representative sample of Chennai City in South India. Skeletal muscle mass was estimated by dual-energy X-ray absorptiometry, and skeletal muscle mass index (SMI) was calculated by dividing the appendicular skeletal muscle mass by the square of the individual’s height in meters and expressed as kg/m2. Presarcopenia was defined as an SMI of £ 7.26 kg/m2 for males and £ 5.5 kg/m2 for females. Biochemical and anthropometric measurements were done using standardized procedures. Results: The 152 participants included 68 women (44.7%). Mean age was 44 – 9 years (range, 28–67 years), and the mean body mass index (BMI) was 25.7 – 3.8 kg/m2. The prevalence rates of presarcopenia among individuals with and without diabetes were 39.5% and 15.8%, respectively (P = 0.001). The mean SMI values were significantly lower in those with diabetes (6.84 – 1.02 kg/m2) compared with participants without diabetes (7.28 – 1.01 kg/m2) (P = 0.009). SMI showed a positive correlation with BMI and waist circumference but a negative correlation with age, fasting plasma glucose, glycated hemoglobin, and low-density lipoprotien cholesterol in the total study population. Logistic regression analysis showed that diabetes was independently associated with presarcopenia (P = 0.001). Conclusions: Prevalence of presarcopenia is higher among Asian Indian subjects with type 2 diabetes compared with ageand sex-matched participants without diabetes.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Prevalence of Presarcopenia; Asian Indian; CURES; Type 2 Diabetes
Subjects:Diabetes > CURES
Diabetes > Diabetes Risk Factors
Diabetology > Diabetes Mellitus Type 2
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:702
Deposited By:surendar radha
Deposited On:07 Oct 2013 15:45
Last Modified:07 Oct 2013 15:45

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