Global Prevalence and Major Risk Factors of Diabetic Retinopathy

Yau, J W Y and Rogers, S L and Kawasaki, R and Lamoureux, E L and Kowalski, J W and Bek, T and Chen, S J and Dekker, J M and Fletcher, A and Grauslund, J and Haffner, S and Hamman, R F and Ikram, M K and Kayama, T and Klein, B E K and Klein, R and Krishnaiah, S and Mayurasakorn, K and O'Hare, J P and Orchard, T J and Porta, M and Rema, M and Roy, M S and Sharma, T and Shaw, J and Taylor, H and Tielsch, J M and Varma, R and Wang, J J and Wang, N and West, S and Xu, Lei and Yasuda, M and Zhang, X and Mitchell, P and Wong, T Y (2012) Global Prevalence and Major Risk Factors of Diabetic Retinopathy. Diabetes Care, 35 (3). p. 556. ISSN 0149-5992



OBJECTIVEdTo examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN ANDMETHODSdA pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence estimates were directly age-standardized to the 2010 World Diabetes Population aged 20–79 years. RESULTSdA total of 35 studies (1980–2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5–34.8) for any DR, 6.96% (6.87–7.04) for proliferative DR, 6.81% (6.74–6.89) for diabetic macular edema, and 10.2% (10.1–10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin A1c, and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONSdThere are approximately 93 million people with DR, 17 million with proliferative DR, 21million with diabeticmacular edema, and 28million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with different methodologies and population characteristics.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Diabetic Retinopathy;Epidemiology/Health Services Research
Subjects:Diabetes > Diabetes Research
Divisions:Department of Opthalmology
ID Code:621
Deposited On:04 Jul 2012 10:12
Last Modified:04 Jul 2012 10:12

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