Increased Levels of Both Th1 and Th2 Cytokines in Subjects with Metabolic Syndrome (CURES-103)

Surendar, J and Mohan, V and Rao, M M and Babu, S and Aravindhan, V (2011) Increased Levels of Both Th1 and Th2 Cytokines in Subjects with Metabolic Syndrome (CURES-103). Diabetes Technology & Therapeutics, 13 (4). p. 477. ISSN 1520-9156

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Objective: Metabolic syndrome (MS) is a cluster of metabolic abnormalities associated with obesity, insulin resistance (IR), dyslipidemia, and hypertension in which inflammation plays an important role. Few studies have addressed the role played by T cell-derived cytokines in MS. The aim of the study was to look at the T-helper (Th) 1 (interleukin [IL]-12, IL-2, and interferon-g [IFN-g]) and Th2 (IL-4, IL-5, and IL-13) cytokines in MS in the high-risk Asian Indian population. Research Design and Methods: Study subjects were recruited from the Chennai Urban Rural Epidemiology Study. MS was defined using National Cholesterol Education Program–Adult Treatment Panel III criteria modified for waist according to World Health Organization Asia Pacific guidelines. Serum cytokine profile was determined by multiplex cytokine assay in subjects with (n¼21) and without (n¼33) MS. Results: Both Th1 and Th2 cytokines showed up-regulation inMS. IL-12 (5.40 pg/mL inMS vs. 3.24 pg/mL in non- MS; P < 0.01), IFN-g (6.8 pg/mL inMS vs. 4.7 pg/mL in non-MS; P < 0.05), IL-4 (0.61 pg/mL in MS vs. 0.34 pg/mL in non-MS; P < 0.001), IL-5 (4.39 pg/mL in MS vs. 2.36 pg/mL in non-MS; P < 0.001), and IL-13 (3.42 pg in MS vs. 2.72 pg/mL in non-MS; P < 0.01) were significantly increased in subjects with MS compared with those without. Both Th1 and Th2 cytokines showed a significant association with fasting plasma glucose level even after adjusting for age and gender. The Th1 and Th2 cytokines also showed a negative association with adiponectin and a positive association with the homeostasis model of assessment of IR and high-sensitivity C-reactive protein. Conclusions: Apart from pro-inflammatory cytokines, Th cytokines might play an important role in inflammation, IR, and MS.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Th2 Cytokines;Metabolic syndrome;CURES-103
Subjects:Islet Cell Transplantation
Divisions:Department of Diabetology
Department of Islet Cell Transplantation
ID Code:576
Deposited On:05 Apr 2011 15:20
Last Modified:05 Apr 2011 15:20

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