Replication of recently described type 2 diabetes gene variants in a South Indian population

Chidambaram, M and Radha, V and Mohan, V (2010) Replication of recently described type 2 diabetes gene variants in a South Indian population. Metabolism, 59 (12). p. 1760. ISSN 00260495

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Abstract

Recent genomewide association studies have identified several new gene variants associated with type 2 diabetes mellitus (T2D) mostly in European populations. These need to be replicated in other populations. We studied 926 unrelated T2D and 812 normal glucose-tolerant subjects randomly selected from the Chennai Urban Rural Epidemiology Study in Southern India. A total of 45 single nucleotide polymorphisms (SNPs) from 15 genes and 13 unannotated loci identified from recent genomewide association T2D studies were genotyped. Only 6 of 45 SNPs studied were replicated in this South Indian population. Three SNPs—rs7756992 (P = .007), rs7754840 (P = .015), and rs6931514 (P = .029)—of the CDKAL1, rs7020996 (P = .003) of the CDKN2A/B gene, rs7923837 (P = .038) of the HHEX gene, and rs12056034 (P = .033) of the BAZ1B gene were associated with T2D in our population. Large-scale studies are needed in our population to validate our findings.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.1016/j.metabol.2010.04.024
Uncontrolled Keywords:type 2 Diabetes; Genitics;South Indian population
Subjects:Diabetes > CURES
Genetics and Diabetes
Divisions:Neonatal Diabetes
Department of Diabetology
ID Code:560
Deposited By:INVALID USER
Deposited On:04 Jan 2011 09:30
Last Modified:04 Jan 2011 09:30

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