Moving to an A1C-Based Diagnosis of Diabetes Has a Different Impact on Prevalence in Different Ethnic Groups

Christensen, D L and Witte, D R and Kaduka, L and Jorgensen, M E and Borch-Johnsen, K and Mohan, V and Shaw, J E and Tabak, A G and Vistisen, D (2010) Moving to an A1C-Based Diagnosis of Diabetes Has a Different Impact on Prevalence in Different Ethnic Groups. Diabetes Care, 33 (3). pp. 580-2. ISSN 0149-5992

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Abstract

OBJECTIVE— To compare screen-detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current oral glucose tolerance test (OGTT)-based and newly proposed A1C-based diagnostic criteria. RESEARCH DESIGN AND METHODS— Six studies (1999–2009) from Denmark, the U.K., Australia, Greenland, Kenya, and India were tested for the probability of an A1C 6.5% among diabetic case subjects based on an OGTT. The difference in probability between centers was analyzed by logistic regression adjusting for relevant confounders. RESULTS— Diabetes prevalence was lower with the A1C-based diagnostic criteria in four of six studies. The probability of an A1C 6.5% among OGTT-diagnosed case subjects ranged widely (17.0–78.0%) by study center. Differences in diagnostic agreement between ethnic subgroups in the U.K. study were of the same magnitude as between-country comparisons. CONCLUSIONS— A shift to an A1C-based diagnosis for diabetes will have substantially different consequences for diabetes prevalence across ethnic groups and populations.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.2337/dc09-1843
Uncontrolled Keywords:Diabetes;A1C;Prevalence in Different Ethnic Groups
Subjects:Diabetes > Diabetes Treatment
Diabetes > CURES
Genetics and Diabetes > Genetic Risk Factors
Diabetes
Divisions:Department of Diabetology
Department of Advanced Research Biochemistry
ID Code:508
Deposited By:INVALID USER
Deposited On:07 May 2010 15:33
Last Modified:07 May 2010 15:33

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