Prevalence and clinical profile of autosomal dominant type 2 diabetes from a diabetes centre in India

Abstract

Aims: To study the prevalence, and clinical profile of autosomal dominant (AD) inherited forms of type 2 diabetes mellitus (T2DM). Methods: Detailed pedigree charts were drawn on 510 consecutive T2DM subjects attending a tertiary care diabetes centre in South India. Clinical and biochemical features of T2DM subjects with and without AD inheritance were compared. Results: Overall, 36.1% of T2DM had one parent with diabetes, in 10.6%, both parents had diabetes and 10.2% had features ofAD.Age at diagnosis of diabeteswas the lowest amongAD group compared to other groups (p for trend <0.001). Only 22.6% ofT2DMwithADinheritance had age at diagnosis of diabetes below 25 years and in 26.4%, it was diagnosed above 45 years. There were no significant differences in the clinical features, including prevalence of diabetic complications, between T2DM with and without AD inheritance. Conclusions: In this clinic-based study, 10.2% of T2DM subjects had evidence of AD inheritance. While the AD cases occurred at younger age, older age at diagnosis was not uncommon. Clinical features, including complications, did not differ between the T2DM patients with or without AD.