Association of thePPARGC1AGene Polymorphism With Diabetic Nephropathy in an Asian Indian Population (CURES-41)

Gayathri, S B and Radha, V and Vimaleswaran, K S and Mohan, V (2009) Association of thePPARGC1AGene Polymorphism With Diabetic Nephropathy in an Asian Indian Population (CURES-41). Metabolic Syndrome and Related Disorders . pp. 1-8. ISSN 1540-4196 (In Press)

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Background: The aim of this study was to evaluate the association of polymorphisms of the peroxisome proliferator- activated receptor gamma (PPARG) gene and peroxisome proliferators-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene with diabetic nephropathy (DN) in Asian Indians. Methods: Six common polymorphisms, 3 of the PPARG gene [−1279G/A, Pro12Ala, and His478His (C/T)] and 3 of the PPARGC1A gene (Thr394Thr, Gly482Ser, and +A2962G) were studied in 571 normal glucose-tolerant (NGT) subjects, 255 type 2 diabetic (T2D) subjects without nephropathy, and 141 DN subjects. Genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and direct sequencing. Logistic regression analysis was performed to assess the covariables associated with DN. Results: Among the 6 polymorphisms examined, only the Gly482Ser of the PPARGC1A gene was signifi cantly associated with DN. The genotype frequency of Ser/Ser genotype of the PPARGC1A gene was 8.8% (50/571) in NGT subjects, 7.8% (20/255) in T2D subjects, and 29.8% (42/141) in DN subjects. The odds ratios (ORs) for DN for the susceptible Gly/Ser and Ser/Ser genotype after adjusting for age, sex, body mass index, and duration of diabetes were 2.14 [95% confi dence interval (CI), 1.23–3.72; P = 0.007] and 8.01 (95% CI, 3.89–16.47; P < 0.001), respectively. The unadjusted OR for DN for the XA genotype of the Thr394Thr polymorphism was 1.87 (95% CI, 1.20–2.92; P = 0.006) compared to T2D subjects. However, the signifi cance was lost (P = 0.061) when adjusted for age, sex, BMI, and duration of diabetes. The +A2962G of PPARGC1A and the 3 polymorphisms of PPARG were not associated with DN. Conclusion: The Gly482Ser polymorphism of the PPARGC1A gene is associated with DN in Asian Indians.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:PPARGC1AGene;Polymorphism;Diabetic Nephropathy;(CURES-41)
Subjects:Diabetes > CURES
Diabetology > Diabetic Nephropathy
Genetics and Diabetes
Divisions:Department of Opthalmology
Neonatal Diabetes
Department of Diabetology
ID Code:449
Deposited On:23 Jan 2010 10:05
Last Modified:23 Jan 2010 10:05

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