Role of Continuous Subcutaneous Insulin Infusion in Patients with Recalcitrant Diabetes in South India

Sudhakaran, C and Anjana, R M and Rao, K and Unnikrishnan, R and Suresh, T and Mohan, V (2009) Role of Continuous Subcutaneous Insulin Infusion in Patients with Recalcitrant Diabetes in South India. Diabetes Technology & Therapeutics, 11 (11). p. 733. ISSN 1520-9156

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Background: We aimed to assess the effect of continuous subcutaneous insulin infusion (CSII) therapy in patients with ‘‘recalcitrant diabetes’’ whose glycemia had not been controlled adequately with multiple daily injections of insulin or insulin plus oral hypoglycemic agents. Patients and Methods: We retrospectively analyzed the medical records of patients with diabetes who were initiated on insulin pump therapy at our center in India between 2002 and 2007. Data analysis included fasting and postprandial blood glucose and glycated hemoglobin (HbA1c) values, insulin requirement, body weight, and the occurrence of hypoglycemia and diabetic ketoacidosis. Results: We studied 33 patients with diabetes (type 1 [n¼17] and type 2 [n¼16]) who were on CSII therapy for a mean duration of 3.4 years. A statistically significant reduction in HbA1c was found after initiating CSII (prepump 10.7%vs. postpump 8.3%, P<0.001). The reduction was greater in type 1 patients (10.62.1 vs. 8.01.6%) than in type 2 patients (11.02.1 vs. 8.81.4%). There was a reduction in frequency of severe hypoglycemia after starting the CSII pump, and there were no instances of diabetic ketoacidosis. Conclusions: Although HbA1c levels did not reach optimal targets, our data indicate that CSII is an effective therapy for patients with diabetes having recalcitrant diabetes who can afford this treatment and whose glycemia is poorly controlled with conventional therapies.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:HbA1c levels;Insulin Infusion;South India
Subjects:Diabetes Clinical Trials
Diabetology > Diabetes Mellitus Type 2
Divisions:Department of Diabetology
Department of Clinical Trials
ID Code:446
Deposited On:22 Jan 2010 10:59
Last Modified:22 Jan 2010 10:59

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