Tropical pancreatic diabetes in South India: heterogeneity in clinical and biochemical profile.

Mohan, V and Mohan, R and Susheela, L and Snehalatha, C and Bharani, G and Mahajan, V K and Ramachandran, A and Viswanathan, M and Kohner, E M (1985) Tropical pancreatic diabetes in South India: heterogeneity in clinical and biochemical profile. Diabetologia, 28 (4). pp. 229-32. ISSN 0012-186X

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Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tropical pancreatic diabetes had clinical evidence of malnutrition. There was no history of cassava ingestion. Mean serum cholesterol concentration was significantly lower in the tropical pancreatic diabetic patients (p less than 0.01) in comparison with the Type 2 diabetic patients or non-diabetic subjects, due to a significantly decreased concentration of LDL cholesterol (p less than 0.01) and VLDL cholesterol (p less than 0.05). Basal and post-glucose stimulated concentrations of serum C-peptide were highest in those pancreatic diabetic patients (n = 11) who responded to oral hypoglycaemic drugs, intermediate in the majority (n = 17), who were insulin dependent and ketosis resistant and negligible in a small sub-group (n = 5) who were ketosis prone. The occurrence of microangiopathy in pancreatic diabetic patients was common and similar to that in Type 2 diabetic patients. Thus, tropical pancreatic diabetes in South India appears to be heterogeneous with respect to level of nutrition, severity of glucose intolerance, B-cell function, response to therapy and the occurrence of microvascular complications.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Tropical pancreatic diabetes;heterogeneity;C-peptide;
Subjects:Genetics and Diabetes
Diabetology > Pancreatic Diabetes
Biochemistry,Cell and Molecular Signalling
Divisions:Neonatal Diabetes
Department of Diabetology
ID Code:405
Deposited On:05 Jan 2010 10:28
Last Modified:05 Jan 2010 10:28
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