HLA-DR and -DQ DNA genotyping in insulin-dependent diabetes patients in South India.

Serjeantson, S W and Ranford, P R and Kirk, R L and Kohonen-Corish, M R and Mohan, V and Ramachandran, A and Snehalatha, C and Viswanathan, M (1987) HLA-DR and -DQ DNA genotyping in insulin-dependent diabetes patients in South India. Disease Markers, 5 (2). pp. 101-8. ISSN 0278-0240

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Abstract

Restriction fragment length polymorphisms (RFLPs) of the HLA-DR beta, -DQ alpha, -DQ beta, and -DX alpha genes have been examined in South Indian diabetic patients and controls. The DR. DQ linkage arrangements in South Indians were shown to be different for DR2, DR4, and DRw6 from those commonly seen in Europeans, so that localization of the primary disease-promoting gene in IDDM could be attempted. This study clearly implicates at least one DQ beta allele in the pathogenesis of IDDM.

Item Type:Article
Official URL/DOI:http://www.iospress.nl/loadtop/load.php?isbn=02780...
Uncontrolled Keywords:HLA-DR;DQ DNA;insulin-dependent diabetes patients
Subjects:Genetics and Diabetes
Diabetology > Insulin Dependent Diabetes Mellitus
Diabetes
Divisions:Neonatal Diabetes
Department of Diabetology
ID Code:381
Deposited By:INVALID USER
Deposited On:02 Jan 2010 10:54
Last Modified:02 Jan 2010 10:57

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