Insulin resistance in maturity onset diabetes of the young.

Mohan, V and Sharp, P S and Aber, V R and Mather, H M and Kohner, E M (1987) Insulin resistance in maturity onset diabetes of the young. Diabète & métabolisme, 13 (3). pp. 193-7. ISSN 0338-1684

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Insulin resistance was assessed by euglycaemic clamp studies in matched groups of MODY, classical NIDDM patients and non-diabetic control subjects. The MODY patients metabolised less glucose (4.8 +/- 0.3 mg/Kg/min) than the classical NIDDM patients (7.0 +/- 0.5 mg/Kg/min) at an insulin infusion rate of 1.0 mU/Kg/min (p less than 0.05). At an insulin infusion rate 10 mU/Kg/min the differences between the MODY and the classical NIDDM patients were not significant. At both infusion rates the two diabetic groups metabolised less glucose than the control subjects. The results indicate that despite their younger age, the patients with MODY are more insulin resistant than the patients with classical NIDDM.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Insulin resistance ;maturity onset diabetes of the young
Subjects:Genetics and Diabetes > Maturity-Onset Diabetes of the Young(MODY)
Genetics and Diabetes
Divisions:Neonatal Diabetes
Department of Diabetology
ID Code:378
Deposited On:02 Jan 2010 10:31
Last Modified:02 Jan 2010 10:31

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