Erythrocyte insulin binding abnormalities in fibro calculous pancreatic diabetes.

Ramachandran, A and Susheela, L and Mohan, V and Kuzali, D A and Viswanathan, M (1988) Erythrocyte insulin binding abnormalities in fibro calculous pancreatic diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, 20 (11). pp. 693-7. ISSN 0018-5043

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Insulin binding to erythrocyte insulin receptors was studied in 17 patients (13 men and 4 women) with fibrocalculous pancreatic diabetes mellitus (FCPD) and compared with that of 14 newly diagnosed NIDDM patients matched for age, sex and severity of hyperglycemia, and 14 age and sex-matched non-diabetic control subjects. In the uncompensated diabetic state, mean (+/- S.D.) specific binding of insulin was lower in both FCPD and NIDDM patients, compared with non-diabetic controls (P less than 0.001). Control of diabetes with short term therapy (2-6 weeks) resulted in a significant improvement in the mean specific insulin binding in both FCPD and NIDDM patients (P less than 0.001) due to increased binding affinity in the former, and increased affinity and the number of binding sites in the latter. As compared to short term therapy, chronic therapy (5-8 months) in FCPD patients resulted in a marginal decrease in specific insulin binding. However, this was still significantly higher than the basal value (P less than 0.05). FCPD patients had an initial low mean basal plasma IRI and a much lower mean stimulated IRI response as compared to NIDDM and non-diabetic controls.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:fibro calculous pancreatic diabetes;FCPD;
Subjects:Genetics and Diabetes
Diabetology > Pancreatic Diabetes
Divisions:Neonatal Diabetes
Department of Diabetology
ID Code:363
Deposited On:30 Dec 2009 10:51
Last Modified:30 Dec 2009 10:51

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