Plasma glucagon responses in tropical fibrocalculous pancreatic diabetes.

Mohan, V and Snehalatha, C and Ramachandran, A and Chari, S and Madanagopalan, N and Viswanathan, M (1990) Plasma glucagon responses in tropical fibrocalculous pancreatic diabetes. Diabetes research and clinical practice, 9 (1). pp. 97-101. ISSN 0168-8227

Restricted to MDRF users only. Others may ->



Plasma insulin and glucagon responses to a glucose load were measured in a group of patients with fibrocalculous pancreatic diabetes (FCPD) and compared with patients with noninsulin-dependent diabetes mellitus (NIDDM) and control subjects. Both diabetic groups had markedly diminished insulin responses but the differences between FCPD and NIDDM groups were not significant. In control subjects, in response to the glucose load, plasma glucagon levels decreased while they increased in NIDDM patients. In FCPD patients there was no significant change in glucagon levels in response to the glucose load. The study shows that FCPD patients lack pancreatic alpha-cell responses to a glucose load. This may play a role in protecting these patients against ketosis.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Plasma glucagon;fibrocalculous pancreatic diabetes;Ketosis resistance
Subjects:Diabetology > Pancreatic Diabetes
Biochemistry,Cell and Molecular Signalling
Divisions:Neonatal Diabetes
Department of Diabetology
Department of Advanced Research Biochemistry
ID Code:333
Deposited On:25 Dec 2009 15:04
Last Modified:25 Dec 2009 15:04

Repository Staff Only: item control page