The BT-PABA/PAS test in tropical diabetes.

Gagee, P and Pemberton, P and Lobley, R and Chaloner, C and Snehalatha, C and Mohan, V and Braganza, J M (1992) The BT-PABA/PAS test in tropical diabetes. Clinica chimica acta; international journal of clinical chemistry, 212 (3). pp. 103-11. ISSN 0009-8981

Restricted to MDRF users only. Others may ->



A 'screening' test is needed to identify patients with chronic pancreatitis among diabetics in tropical field surveys. We have examined the potential diagnostic yield of the BT-PABA/PAS test of exocrine pancreatic function in this setting. The recoveries of both PABA and PAS in eight healthy controls from Madras, south India, were lower than in controls from Manchester, north west England (mean +/- S.D., 51 +/- 11 vs. 79 +/- 7%, P < 0.001 for PABA; 52 +/- 11% vs. 81 +/- 7%, P < 0.001 for PAS) but the % PABA/PAS excretion index (PEI) was similar (0.96 +/- 0.14 vs. 0.96 +/- 0.06). Using a cut-off value of 0.75 for the PEI in a study group including eight patients with chronic pancreatitis and 26 with primary forms of diabetes, test sensitivity was 75%, specificity 92%, positive predictive value 75%, negative predictive value 92% and efficiency 88%.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Tropical diabetes; BT-PABA/PAS test; Fluorimetry; Chronic pancreatitis
Subjects:Diabetology > Pancreatic Diabetes
Divisions:Department of Diabetology
Department of Advanced Research Biochemistry
ID Code:315
Deposited On:22 Dec 2009 09:30
Last Modified:22 Dec 2009 09:30

Repository Staff Only: item control page