Antioxidant status and lipid peroxidation in type II diabetes mellitus with and without complications.

Sundaram, R K and Bhaskar, A and Vijayalingam, S and Viswanathan, M and Mohan, R and Shanmugasundaram, K R (1996) Antioxidant status and lipid peroxidation in type II diabetes mellitus with and without complications. Clinical science (London, England : 1979), 90 (4). pp. 255-60. ISSN 0143-5221

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Abstract

1. This study was conducted on 467 cases of non-insulin-dependent diabetes mellitus and 180 healthy controls. Lipid peroxidation products in plasma and erythrocytes were assayed as thiobarbituric acid reactive substances, along with the erythrocyte antioxidant enzymes, namely superoxide dismutase, catalase and glutathione peroxidase. In addition, scavenger vitamins A, C and E and reduced glutathione levels in blood were also measured. 2. Lipid peroxidation was significantly raised within the first 2 years of diagnosis, and superoxide dismutase, catalase, reduced glutathione and vitamins C and E were significantly lowered. 3. These changes were correlated with the duration of the disease and were of a higher magnitude with the development of complications. 4. The results suggest that the antioxidant deficiency and excessive peroxide-mediated damage may appear early on in non-insulin-dependent diabetes mellitus, before the development of secondary complications.

Item Type:Article
Official URL/DOI:http://www.clinsci.org/cs/090/cs0900255.htm
Uncontrolled Keywords:type II diabetes mellitus;lipid peroxidation
Subjects:Diabetology > Diabetes Mellitus Type 2
Biochemistry,Cell and Molecular Signalling
Divisions:Department of Diabetology
Department of Advanced Research Biochemistry
ID Code:287
Deposited By:INVALID USER
Deposited On:16 Dec 2009 11:55
Last Modified:16 Dec 2009 11:55

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