Orally active insulin mimics: where do we stand now?

Balasubramanyam, M and Mohan, V (2001) Orally active insulin mimics: where do we stand now? Journal of biosciences, 26 (3). pp. 383-90. ISSN 0250-5991



The war against diabetes through the development of new drugs is an ongoing continuous process to counter the alarming global increase in the prevalence of diabetes and its complications, particularly in developing countries like India. Unfortunately, the speed with which our knowledge of diabetes and its effects is expanding is not matched by the availability of new drugs. Following the identification of the insulin receptor (IR), its intrinsic kinase activity and molecular cloning, many studies have looked at IR as an ideal drug target. This review summarizes in brief the latest advancements in this field with particular reference to the current situation in respect of the development of orally active insulin mimetics in the treatment of type 2 diabetes.

Item Type:Article
Official URL/DOI:http://www.ias.ac.in/jbiosci/sep2001/383.pdf
Uncontrolled Keywords:Insulin mimetic; insulin receptor tyrosine kinase; PI 3-kinase; vanadium
Subjects:Biochemistry,Cell and Molecular Signalling > Cellular Aspects-Insulin Resistence
Diabetology > Insulin Dependent Diabetes Mellitus
Divisions:Department of Cell and Molecular Biology
Department of Diabetology
ID Code:248
Deposited On:05 Dec 2009 09:31
Last Modified:05 Dec 2009 09:31
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