Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes.

Mohan, V and Deepa, R and Bhatia, E and Singh, A K and Hitman, G A and Zimmet, P Z and MacKay, I R (1998) Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes. Diabetic medicine : a journal of the British Diabetic Association, 15 (2). pp. 156-9. ISSN 0742-3071

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Abstract

Fibrocalculous pancreatic diabetes (FCPD) is a type of diabetes secondary to tropical chronic non-alcoholic pancreatitis. Little is known about the aetiopathogenesis of FCPD. We studied glutamic acid decarboxylase antibodies (GAD-Ab) and islet cell antibodies (ICA) in patients with FCPD and compared the results with Type 1 (insulin dependent) diabetes mellitus, Type 2 (non-insulin-dependent) diabetes mellitus and non-diabetic subjects in Southern India. The prevalence of GAD-Ab was 7.0% (95% Confidence Interval (CI) 1.9-17.2) in FCPD, 47.5% (CI 31.4-64.0) in Type 1 (p < 0.001 compared to FCPD), 5.6% (CI 1.5-13.9) in Type 2 (non-significant (NS) compared to FCPD) and 0% in controls. The prevalence of ICA was 6.3% (CI 1.2-17.4) in FCPD, 53.8% (CI 37.1-70.0) in Type 1 (p < 0.001 compared to FCPD), 9.9% (CI 4.0-19.4) in Type 2 (NS compared to FCPD) and 4.7% (CI 0.4-16.1) in controls. The data suggest that in FCPD, the frequency of auto-antibodies is low and its aetiology is probably not linked to autoimmunity in the majority of the patients.

Item Type:Article
Official URL/DOI:http://www.wiley.com/bw/journal.asp?ref=0742-3071
Uncontrolled Keywords:Antibodies;pancreatic;pancreatic diabetes
Subjects:Diabetes > Diabetes Management
Diabetology > Pancreatic Diabetes
Divisions:Neonatal Diabetes
Department of Diabetology
Department of Advanced Research Biochemistry
ID Code:230
Deposited By:INVALID USER
Deposited On:02 Dec 2009 12:04
Last Modified:02 Dec 2009 12:04
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