Tropical chronic pancreatitis: an update.

Mohan, V and Premalatha, G and Pitchumoni, C S (2003) Tropical chronic pancreatitis: an update. Journal of clinical gastroenterology, 36 (4). pp. 337-46. ISSN 0192-0790

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Tropical chronic pancreatitis represents a juvenile nonalcoholic form of chronic pancreatitis prevalent in many tropical developing countries. Tropical chronic pancreatitis differs from temperate zone pancreatitis in its younger age of onset, more accelerated course, higher prevalence of pancreatic calculi and diabetes, and greater propensity to pancreatic malignancy. The diabetic stage of the disease is referred to as fibrocalculous pancreatic diabetes. The diabetes is severe and insulin requiring although ketosis resistant. Diabetic complications occur in fibrocalculous pancreatic diabetes just like in other primary forms of diabetes. The etiology of tropical chronic pancreatitis remains unclear, although malnutrition along with dietary cyanogen toxicity, antioxidant deficiency, and a genetic predisposition have been proposed. In the last few decades, the prognosis has markedly improved as a result of better management of diabetes. Yet a better understanding of the pathogenesis of tropical chronic pancreatitis could further improve treatment options and offer an opportunity for prevention of this disorder, which leads to severe morbidity in a large proportion of affected patients.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Tropical chronic pancreatitis—Fibrocalculous pancreatic diabetes;Cassava;Immunohistochemistry; Complications
Subjects:Diabetes > Diabetes Research
Diabetology > Pancreatic Diabetes
Divisions:Department of Diabetology
ID Code:159
Deposited On:05 Nov 2009 13:17
Last Modified:05 Nov 2009 13:17
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