Association of serum lipids with diabetic retinopathy in urban South Indians—the Chennai Urban Rural Epidemiology Study (CURES) Eye Study—2

Rema, M and Srivastava, B K and Anitha, B and Deepa, R and Mohan, V (2006) Association of serum lipids with diabetic retinopathy in urban South Indians—the Chennai Urban Rural Epidemiology Study (CURES) Eye Study—2. Diabetic Medicine, 23 (9). pp. 1029-36. ISSN 0742-3071



Aims To study the association of serum lipids with diabetic retinopathy (DR) in Type 2 diabetic subjects. Methods Type 2 diabetic subjects ( n = 1736) were randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), which was carried out on a representative population of Chennai in South India. DR was diagnosed by retinal colour photography and classified according to the Early Treatment Diabetic Retinopathy Study (ETDRS) grading system. Classification of lipid abnormalities was done according to the National Cholesterol Education Programme–Adult Treatment Panel III (NCEP–ATP III) Guidelines. Results The mean serum cholesterol ( P = 0.024), serum triglycerides ( P = 0.017) and non-high-density lipoprotein (HDL)-cholesterol ( P = 0.025) concentrations were higher in subjects with DR compared with those without DR. Multiple logistic regression analysis revealed that after adjusting for age, gender, duration of diabetes, total cholesterol Standardised regression estimate (SRE) = 1.178, 95% confidence interval (CI) 1.042, 1.331, P = 0.014), non-HDL-cholesterol (SRE = 1.169, 95% CI 1.040, 1.313, P = 0.012) and serum triglycerides (SRE = 1.292, 95% CI 1.136, 1.467, P = 0.001) were associated with DR and non-HDL-cholesterol (SRE = 1.264, 95% CI 1.000, 1.592, P = 0.045) and lowdensity lipoprotein (LDL)-cholesterol (SRE = 1.453, 95% CI 1.107, 1.896, P = 0.005) with diabetic macular oedema (DME). After adjusting for HbA 1c and body mass index, only triglycerides maintained a significant association with DR (SRE = 1.137, 95% CI 1.000, 1.291, P = 0.007) and LDL-cholesterol with macular oedema (SRE = 1.358, 95% CI 1.034, 1.774, P = 0.026). Conclusions There is a significant association of serum triglycerides with DR and LDL-cholesterol with DME.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:diabetic retinopathy; lipids; non-HDL-cholesterol; South Indians;triglycerides
Subjects:Diabetes > CURES
Diabetes Clinical Trials > Lipid Lowering Drugs
Diabetology > Retino Diabetology
Diabetes Epidemiology
Divisions:Department of Opthalmology
Department of Epidemiology
Department of Diabetology
ID Code:156
Deposited On:04 Nov 2009 09:54
Last Modified:04 Nov 2009 09:54
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