Association of cognitive impairment with sleep quality, depression and cardiometabolic risk factors in individuals with type 2 diabetes mellitus: A cross sectional study

Gupta, A and Gupta, Y and Anjana, R M and Ranjani, H and Kalaivani, M and Goyal, A and Jagannathan, N and Sharma, S and Mittal, B and Radhakrishnan, V K and Garg, V and Sharma, G and Jyotsna , V P and Sagar, R and Mohan, V and Tandon, N (2024) Association of cognitive impairment with sleep quality, depression and cardiometabolic risk factors in individuals with type 2 diabetes mellitus: A cross sectional study. Journal of Diabetes and its Complications, 35 (8). p. 107970.

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Abstract

Aim: The aim of this study was to evaluate the association of cognitive impairment with sleep quality, depression, and cardiometabolic risk factors among participants with type 2 diabetes mellitus. Methods: Subjects underwent clinical interview to capture socio-demographic details, medical history, sleep quality, presence of depression, along with anthropometric and biochemical measurements. A detailed neuropsychological assessment [Montreal cognitive assessment scale (MoCA), Trail making A and B, Digit span, Spatial span, Letter Number Sequencing] was done. Cognitive impairment was defined as MoCA score of <23. Results: Participants (n=250, 50% women, 63.6% middle-age) had a mean (±SD) age of 53.6 (±9.1) years and HbA1c of 55.1±6.8mmol/mol (7.2±0.6%). Cognitive impairment was present in 57 (22.8%) participants. In the middle-age subgroup, cognitive impairment was higher (23.9%) than those in the fourth decade (6.3%), but comparable (24.0%) to the older age (60-70years) individuals. Diabetes-related vascular complications [Odds ratio (95% CI) 2.03 (1.05, 3.94)]; hypertension [2.00 (1.04, 3.84)], depression [2.37 (1.24, 4.55)] and lower education [2.73 (1.42, 5.23)] had a significant association with cognitive impairment on multivariate logistic regression analysis. Conclusion: The high burden of cognitive impairment calls for an urgent need to establish longitudinal cohorts in midlife to understand this population's cognitive trajectories and see the influence of various bio-psychosocial variables.

Item Type:Article
Official URL/DOI:https://www.sciencedirect.com/journal/journal-of-d...
Uncontrolled Keywords:Asia; Cognition; Cognitive impairment; Complications; Depression; Diabetes; Middle-age; MoCA; Sleep.
Subjects:Diabetology > Diabetes Mellitus Type 2
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:1455
Deposited By:surendar radha
Deposited On:28 Jun 2024 10:17
Last Modified:28 Jun 2024 10:17

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