Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review

Bodhini, D and Morton, R W and Santhakumar, V and Nakabuye, M and Pomares, M H and Clemmensen, C and Fitzpatrick, S L and Guasch, F M and Pankow, J M and Larsen, M R and Franks, P W and Tobias, D K and Merino, J and Mohan, V and Loos, Ruth J F (2023) Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review. Communications Medicine, 3 (133).

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Abstract

Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier. Results: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. Conclusions: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.

Item Type:Article
Official URL/DOI:https://www.nature.com/articles/s43856-023-00363-0
Uncontrolled Keywords:type 2 diabetes
Subjects:Diabetology > Diabetes Mellitus Type 2
Diabetes
Divisions:Department of Cell and Molecular Biology
Department of Diabetology
ID Code:1412
Deposited By:surendar radha
Deposited On:24 Nov 2023 13:44
Last Modified:24 Nov 2023 13:44

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