Lower Dietary Intake of Plant Protein Is Associated with Genetic Risk of Diabetes-Related Traits in Urban Asian Indian Adults

Alsulami, S and Bodhini, D and Sudha, V and Shanthi Rani, C S and Pradeepa, R and Anjana, R M and Radha, V and Lovegrove, J A and Gayathri, R and Mohan, V and Vimaleswaran, K S (2021) Lower Dietary Intake of Plant Protein Is Associated with Genetic Risk of Diabetes-Related Traits in Urban Asian Indian Adults. Nutrients, 13 (9). p. 3064. ISSN 2072-6643



The increasing prevalence of type 2 diabetes among South Asians is caused by a complex interplay between environmental and genetic factors. We aimed to examine the impact of dietary and genetic factors on metabolic traits in 1062 Asian Indians. Dietary assessment was performed using a validated semi-quantitative food frequency questionnaire. Seven single nucleotide polymorphisms (SNPs) from the Transcription factor 7-like 2 and fat mass and obesity-associated genes were used to construct two metabolic genetic risk scores (GRS): 7-SNP and 3-SNP GRSs. Both 7-SNP GRS and 3-SNP GRS were associated with a higher risk of T2D (p = 0.0000134 and 0.008, respectively). The 3-SNP GRS was associated with higher waist circumference (p = 0.010), fasting plasma glucose (FPG) (p = 0.002) and glycated haemoglobin (HbA1c) (p = 0.000066). There were significant interactions between 3-SNP GRS and protein intake (% of total energy intake) on FPG (Pinteraction = 0.011) and HbA1c (Pinteraction = 0.007), where among individuals with lower plant protein intake (<39 g/day) and those with >1 risk allele had higher FPG (p = 0.001) and HbA1c (p = 0.00006) than individuals with ≤1 risk allele. Our findings suggest that lower plant protein intake may be a contributor to the increased ethnic susceptibility to diabetes described in Asian Indians. Randomised clinical trials with increased plant protein in the diets of this population are needed to see whether the reduction of diabetes risk occurs in individuals with prediabetes.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.3390/nu13093064
Uncontrolled Keywords:T2D; dietary protein intake; genetic risk score; gene–diet interaction; metabolic traits; urban Asian Indian
Subjects:Biochemistry,Cell and Molecular Signalling > Genomics in Diabetes
Divisions:Department of Advanced Research Biochemistry
ID Code:1266
Deposited By:surendar radha
Deposited On:19 Oct 2021 11:35
Last Modified:19 Oct 2021 11:35

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