Identification of African-Specific Admixture between Modern and Archaic Humans

Wall, Jeffrey D. and Ratan, Aakrosh and Stawiski, Eric and Wall, Jeffrey D. and Stawiski, Eric and Ratan, Aakrosh and Kim, Hie Lim and Kim, Changhoon and Gupta, Ravi and Suryamohan, Kushal and Gusareva, Elena S. and Purbojati, Rikky Wenang and Bhangale, Tushar and Stepanov, Vadim and Kharkov, Vladimir and Schrӧder, Markus S. and Ramprasad, Vedam and Tom, Jennifer and Durinck, Steffen and Bei, Qixin and Li, Jiani and Guillory, Joseph and Phalke, Samir and Basu, Analabha and Stinson, Jeremy and Nair, Sandhya and Malaichamy, Sivasankar and Biswas, Nidhan K. and Chambers, John C. and Cheng, Keith C. and George, Joyner T. and Khor, Seik Soon and Kim, Jong-Il and Cho, Belong and Menon, Ramesh and Sattibabu, Thiramsetti and Bassi, Akshi and Deshmukh, Manjari and Verma, Anjali and Gopalan, Vivek and Shin, Jong-Yeon and Pratapneni, Mahesh and Santhosh, Sam and Tokunaga, Katsushi and Md-Zain, Badrul M. and Chan, Kok Gan and Parani, Madasamy and Natarajan, Purushothaman and Hauser, Michael and Allingham, R. Rand and Santiago-Turla, Cecilia and Ghosh, Arkasubhra and Gadde, Santosh Gopi Krishna and Fuchsberger, Christian and Forer, Lukas and Shoenherr, Sebastian and Sudoyo, Herawati and Lansing, J. Stephen and Friedlaender, Jonathan and Koki, George and Cox, Murray P. and Hammer, Michael and Karafet, Tatiana and Ang, Khai C. and Mehdi, Syed Q. and Radha, V and Mohan, V and Majumder, Partha P. and Seshagiri, Sekar and Seo, Jeong-Sun and Schuster, Stephan and Peterson, Andrew S. (2019) Identification of African-Specific Admixture between Modern and Archaic Humans. The American Journal of Human Genetics, 105 (6). pp. 1254-1261. ISSN 00029297

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Abstract

Recent work has demonstrated that two archaic human groups (Neanderthals and Denisovans) interbred with modern humans and contributed to the contemporary human gene pool. These findings relied on the availability of high-coverage genomes from both Neanderthals and Denisovans. Here we search for evidence of archaic admixture from a worldwide panel of 1,667 individuals using an approach that does not require the presence of an archaic human reference genome. We find no evidence for archaic admixture in the Andaman Islands, as previously claimed, or on the island of Flores, where Homo floresiensis fossils have been found. However, we do find evidence for at least one archaic admixture event in sub-Saharan Africa, with the strongest signal in Khoesan and Pygmy individuals from Southern and Central Africa. The locations of these putative archaic admixture tracts are weighted against functional regions of the genome, consistent with the long-term effects of purifying selection against introgressed genetic material.

Item Type:	Article
Official URL/DOI:	http://dx.doi.org/10.1016/j.ajhg.2019.11.005
Uncontrolled Keywords:	Denisovan; GenomeAsia project; Neanderthal; archaic humans; ghost admixture
Subjects:	Genetics and Diabetes
Divisions:	Department of Diabetology Department of Advanced Research Biochemistry
ID Code:	1254
Deposited By:	surendar radha
Deposited On:	05 Aug 2021 14:02
Last Modified:	05 Aug 2021 14:02

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