Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults: A Meta-analysis

Ahuja, V and Aronen, P and Pramodkumar, T A and Looker, H and Chetrit, A and Bloigu, A H and Juutilainen, A and Bianchi, C and La Sala, L and Anjana, R M and Pradeepa, R and Venkatesan, U and Jebarani, S and Baskar, V and Fiorentino, T V and Timpel, P and DeFronzo, R A and Ceriello, A and Del Prato, S and Abdul-Ghani, M and Keinänen-Kiukaanniemi, Sirkka and Dankner, Rachel and Bennett, Peter H and Knowler, William C and Schwarz, Peter and Sesti, Giorgio and Oka, Rie and Mohan, V and Groop, Leif and Tuomilehto, Jaakko and Ripatti, Samuli and Bergman, Michael and Tuomi, Tiinamaija (2021) Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults: A Meta-analysis. Diabetes Care, 44 (4). p. 1062. ISSN 0149-5992

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Objective: One-hour plasma glucose (1-h PG) during the oral glucose tolerance test (OGTT) is an accurate predictor of type 2 diabetes. We performed a meta-analysis to determine the optimum cutoff of 1-h PG for detection of type 2 diabetes using 2-h PG as the gold standard. Research design and methods: We included 15 studies with 35,551 participants from multiple ethnic groups (53.8% Caucasian) and 2,705 newly detected cases of diabetes based on 2-h PG during OGTT. We excluded cases identified only by elevated fasting plasma glucose and/or HbA1c. We determined the optimal 1-h PG threshold and its accuracy at this cutoff for detection of diabetes (2-h PG ≥11.1 mmol/L) using a mixed linear effects regression model with different weights to sensitivity/specificity (2/3, 1/2, and 1/3). Results: Three cutoffs of 1-h PG, at 10.6 mmol/L, 11.6 mmol/L, and 12.5 mmol/L, had sensitivities of 0.95, 0.92, and 0.87 and specificities of 0.86, 0.91, and 0.94 at weights 2/3, 1/2, and 1/3, respectively. The cutoff of 11.6 mmol/L (95% CI 10.6, 12.6) had a sensitivity of 0.92 (0.87, 0.95), specificity of 0.91 (0.88, 0.93), area under the curve 0.939 (95% confidence region for sensitivity at a given specificity: 0.904, 0.946), and a positive predictive value of 45%. Conclusions: The 1-h PG of ≥11.6 mmol/L during OGTT has a good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator to identify high-risk individuals is suggested to decrease the proportion of false-positive cases. Studies including other ethnic groups and assessing complication risk are warranted.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:1 Hour Plasma Glucose
Subjects:Diabetes Epidemiology
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:1222
Deposited By:surendar radha
Deposited On:24 Jul 2021 16:07
Last Modified:24 Jul 2021 16:07

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