ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes.

Abate, Nicola and Chandalia, M and Satija, P and Adams-Huet, B and Grundy, S M and Sandeep, S and Radha, V and Deepa, R and Mohan, V (2005) ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes, 54 (4). pp. 1207-13. ISSN 0012-1797



Genetic susceptibility modulates the impact of obesity on risk for type 2 diabetes. The present study evaluates the role of ENPP1 K121Q polymorphism in prediction of type 2 diabetes in three populations that differ in susceptibility to diabetes and environmental exposure. The three cohorts included 679 nonmigrant South Asians living in Chennai, India (223 with type 2 diabetes); 1,083 migrant South Asians living in Dallas, Texas (121 with type 2 diabetes); and 858 nonmigrant Caucasians living in Dallas, Texas (141 with type 2 diabetes). Patients with type 2 diabetes were included in these cohorts if they had diabetes onset before the age of 60 years. The prevalence of subjects carrying the polymorphic ENPP1 121Q allele was 25% in the nondiabetic group and 34% in the diabetic group of South Asians living in Chennai (P = 0.01). The prevalence in the nondiabetic and diabetic groups were 33 and 45% (P = 0.01) for the South Asians living in Dallas and 26 and 39% (P = 0.003) for the Caucasians. Although further replication studies are necessary to test the validity of the described genotype-phenotype relationship, our study supports the hypothesis that ENPP1 121Q predicts genetic susceptibility to type 2 diabetes in both South Asians and Caucasians.

Item Type:Article
Official URL/DOI:http://diabetes.diabetesjournals.org/content/54/4/...
Uncontrolled Keywords:type 2 diabetes;ENPP1;PC-1 K121Q polymorphism ;genetic susceptibility
Subjects:Diabetes > CURES
Diabetes Epidemiology
Diabetology > Diabetes Mellitus Type 2
Divisions:Neonatal Diabetes
Department of Diabetology
ID Code:120
Deposited On:26 Oct 2009 10:15
Last Modified:26 Oct 2009 10:15

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