Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

Alvarez-Silva, Camila and Kashani, Alireza and Hansen, Tue Haldor and Pinna, Nishal Kumar and Anjana, R M and Dutta, Anirban and Saxena, Shruti and Støy, Julie and Kampmann, Ulla and Nielsen, Trine and Jørgensen, Torben and Gnanaprakash, V and Gnanavadivel, R and Sukumaran, Aswath and Rani, C S S and Færch, Kristine and Radha, V and Balasubramanyam, M and Nair, Gopinath Balakrish and Das, Bhabatosh and Vestergaard, Henrik and Hansen, Torben and Mande, Sharmila Shekhar and Mohan, V and Arumugam, Manimozhiyan and Pedersen, Oluf (2021) Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India. Genome Medicine, 13 (1). ISSN 1756-994X

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Background: Type 2 diabetes (T2D), a multifactorial disease influenced by host genetics and environmental factors, is the most common endocrine disease. Several studies have shown that the gut microbiota as a close-up environmental mediator influences host physiology including metabolism. The aim of the present study is to examine the compositional and functional potential of the gut microbiota across individuals from Denmark and South India with a focus on T2D. Many earlier studies have investigated the microbiome aspects of T2D, and it has also been anticipated that such microbial associations would be dependent on diet and ethnic origin. However, there has been no large scale trans-ethnic microbiome study earlier in this direction aimed at evaluating any“universal” microbiome signature of T2D. Methods: 16S ribosomal RNA gene amplicon sequencing was performed on stool samples from 279 Danish and 294 Indian study participants. Any differences between the gut microbiota of both populations were explored using diversity measures and negative binomial Wald tests. Study samples were stratified to discover global and countryspecific microbial signatures for T2D and treatment with the anti-hyperglycemic drug, metformin. To identify taxonomical and functional signatures of the gut microbiota for T2D and metformin treatment, we used alpha and beta diversity measures and differential abundances analysis, comparing metformin-naive T2D patients, metformintreated T2D patients, and normoglycemic individuals.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:Gut microbiota, Trans-ethnic, Indians, Danes, Populations, Type 2 diabetes, Metformin
Subjects:Biochemistry,Cell and Molecular Signalling > Genomics in Diabetes
Divisions:Department of Cell and Molecular Biology
Department of Diabetology
ID Code:1196
Deposited By:surendar radha
Deposited On:16 Mar 2021 15:23
Last Modified:16 Mar 2021 15:23

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