Precision Medicine with Sulfonylureas: From Clinical Studies to Bedside Practice

Abstract

Precision medicine is part of personalized therapy that is based on an individual’s genetic/epigenetic imprints, lifestyle, and environmental characteristics. Recent advances in understanding of the genomic landscape in diabetes mellitus have identified genetic polymorphisms associated with the risk of diabetes mellitus along with other related complications such as cardiovascular risk or hypoglycemia, in turn, spurring the development of precision medicine in prevention and management of diabetes mellitus. Here we will discuss the various genetic polymorphisms that are currently being explored for the development of precision medicine with sulfonylureas, such as glimepiride, for management of people with diabetes.