Efficacy of the Modern SU Glimepiride in Reducing Hyperglycemia in T2DM

Abstract

Sulfonylureas (SUs) have been used for several decades for diabetes therapy, but the risk of severe hypoglycemia and weight gain associated with this class of drugs has rendered them a subject of controversy. In this context, modern SUs such as glimepiride have emerged as potentially safe and effective candidates for both monotherapy and combination therapy with other antidiabetic drugs such as metformin. Several clinical studies have validated the beneficial effects of glimepiride. A few such studies have established glimepiride as a relatively more potent antidiabetic drug vs. other SUs. Such studies indicate the potential of glimepiride as a preferred drug in the therapy of people with type 2 diabetes mellitus (T2DM). Here we will discuss the efficacy of glimepiride in reducing hyperglycemia in T2DM.