1,5 Anhydroglucitol in gestational diabetes mellitus

Pramodkumar, T A and Jayashri, R and Gokulakrishnan, K and Velmurugan, K and Pradeepa, R and Venkatesan, U and Saravanan, P and Uma, R and Anjana, R M and Mohan, V (2019) 1,5 Anhydroglucitol in gestational diabetes mellitus. Journal of Diabetes and its Complications, 33 (3). p. 231. ISSN 10568727



OBJECTIVE: 1,5 Anhydroglucitol (1,5 AG) is reported to be a more sensitive marker of glucose variability and short-term glycemic control (1-2 weeks) in patients with type1 and type 2 diabetes. However, the role of 1,5 AG in gestational diabetes mellitus (GDM) is not clear. We estimated the serum levels of 1,5 AG in pregnant women with and without GDM. METHODS: We recruited 220 pregnant women, 145 without and 75 with GDM visiting antenatal clinics in Tamil Nadu in South India. Oral glucose tolerance tests (OGTTs) were carried out using 82.5 g oral glucose (equivalent to 75 g of anhydrous glucose) and GDM was diagnosed based on the International Association of Diabetes and Pregnancy Study Group criteria. Serum 1,5 AG levels were measured using an enzymatic, colorimetric assay kit (Glycomark®, New York, NY). Receiver operating characteristic (ROC) curves were used to identify 1,5 AG cut-off points to identify GDM. RESULTS: The mean levels of the 1,5 AG were significantly lower in women with GDM (11.8 ± 5.7 μg/mL, p < 0.001) compared to women without GDM (16.2 ± 6.2 μg/mL). In multiple logistic regression analysis, 1.5 AG showed a significant association with GDM (odds ratio [OR]: 0.876, 95% confidence interval [CI]: 0.812-0.944, p < 0.001) after adjusting for potential confounders. 1,5 AG had a C statistic of 0.693 compared to Fructosamine (0.671) and HbA1c (0.581) for identifying GDM. A 1,5 AG cut-off of 13.21 μg/mL had a C statistic of 0.6936 (95% CI: 0.6107-0.7583, p < 0.001), sensitivity of 67.6%, and specificity of 65.3% to identify GDM. CONCLUSION: 1,5AG levels are lower in pregnant women with GDM compared to individuals without GDM.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.1016/j.jdiacomp.2018.11.010
Uncontrolled Keywords:1,5 Anhydroglucitol; Gestational diabetes mellitus; Glycated hemoglobin; Glycemic variability; Oral glucose tolerance test; Receiver operating characteristics
Subjects:Diabetology > Gestational Diabetes
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:1144
Deposited By:surendar radha
Deposited On:06 Sep 2019 15:12
Last Modified:06 Sep 2019 15:12

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