Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study

Dehghan, Mahshid and Mente, Andrew and Rangarajan, Sumathy and Sheridan, Patrick and Mohan, V and Iqbal, Romaina and Gupta, Rajeev and Lear, Scott and Wentzel-Viljoen, Edelweiss and Avezum, Alvaro and Lopez-Jaramillo, Patricio and Mony, Prem and Varma, Ravi Prasad and Kumar, Rajesh and Chifamba, Jephat and Alhabib, Khalid F and Mohammadifard, Noushin and Oguz, Aytekin and Lanas, Fernando and Rozanska, Dorota and Bostrom, Kristina Bengtsson and Yusoff, Khalid and Tsolkile, Lungiswa P and Dans, Antonio and Yusufali, AfzalHussein and Orlandini, Andres and Poirier, Paul and Khatib, Rasha and Hu, Bo and Wei, Li and Yin, Lu and Deeraili, Ai and Yeates, Karen and Yusuf, Rita and Ismail, Noorhassim and Mozaffarian, Dariush and Teo, Koon and Anand, Sonia S and Yusuf, Salim (2018) Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study. The Lancet, 392 (10161). p. 2288. ISSN 01406736



BACKGROUND: Dietary guidelines recommend minimising consumption of whole-fat dairy products, as they are a source of saturated fats and presumed to adversely affect blood lipids and increase cardiovascular disease and mortality. Evidence for this contention is sparse and few data for the effects of dairy consumption on health are available from low-income and middle-income countries. Therefore, we aimed to assess the associations between total dairy and specific types of dairy products with mortality and major cardiovascular disease. METHODS: The Prospective Urban Rural Epidemiology (PURE) study is a large multinational cohort study of individuals aged 35-70 years enrolled from 21 countries in five continents. Dietary intakes of dairy products for 136 384 individuals were recorded using country-specific validated food frequency questionnaires. Dairy products comprised milk, yoghurt, and cheese. We further grouped these foods into whole-fat and low-fat dairy. The primary outcome was the composite of mortality or major cardiovascular events (defined as death from cardiovascular causes, non-fatal myocardial infarction, stroke, or heart failure). Hazard ratios (HRs) were calculated using multivariable Cox frailty models with random intercepts to account for clustering of participants by centre.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:PURE; Cardiovascular disease;
Subjects:Diabetes Epidemiology
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:1114
Deposited By:surendar radha
Deposited On:12 Dec 2018 15:13
Last Modified:12 Dec 2018 15:13

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