Genetic basis of monogenic diabetes

Radha, V and Mohan, V (2017) Genetic basis of monogenic diabetes. Current Science , 113 (7). p. 1277.



Advances in the understanding of monogenic causes of diabetes and the discovery of single-gene mutations responsible for different phenotypes have greatly increased our knowledge of  -cell physiology. Such advances have had implications for the individual patient diagnosed with the specific monogenic cause of diabetes, especially in maturity onset diabetes of the young (MODY) and neonatal diabetes mellitus (NDM). Genetic diagnosis of MODY is also likely to have important prognostic and therapeutic implications in majority of the patients with confirmed HNF1A and HNF4A mutations. Genetic screening and analyses have helped several neonatal infants carrying mutations in the KCNJ11 and ABCC8 genes to shift from insulin treatment to oral sulphonylurea drugs. The progress in genomics of monogenic diabetic forms has helped in translating the discoveries from bench to bedside in clinical care. Therefore, there is an urgent need to incorporate genetic testing for the genes implicated in monogenic diabetes like MODY and NDM in the diabetes clinics. Discoveries in genetic research methodology and understanding of genetic etiology will have great translatio

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:genetics, monogenic diabetes
Subjects:Genetics and Diabetes
Divisions:Department of Cell and Molecular Biology
ID Code:1063
Deposited By:surendar radha
Deposited On:26 Oct 2017 10:50
Last Modified:26 Oct 2017 10:50

Repository Staff Only: item control page