Comparison of multiple obesity indices for cardiovascular disease risk classification in South Asian adults: The CARRS Study

Kiechl, S and Patel, S A and Deepa, M and Shivashankar, R and Ali, M K and Kapoor, D and Gupta, R and Lall, D and Tandon, N and Mohan, V and Kadir, M M and Fatmi, Z A and Prabhakaran, D and Narayan, K M V (2017) Comparison of multiple obesity indices for cardiovascular disease risk classification in South Asian adults: The CARRS Study. PLOS ONE, 12 (4). e0174251. ISSN 1932-6203



BACKGROUND: We comparatively assessed the performance of six simple obesity indices to identify adults with cardiovascular disease (CVD) risk factors in a diverse and contemporary South Asian population. METHODS: 8,892 participants aged 20-60 years in 2010-2011 were analyzed. Six obesity indices were examined: body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), waist-hip ratio (WHR), log of the sum of triceps and subscapular skin fold thickness (LTS), and percent body fat derived from bioelectric impedance analysis (BIA). We estimated models with obesity indices specified as deciles and as continuous linear variables to predict prevalent hypertension, diabetes, and high cholesterol and report associations (prevalence ratios, PRs), discrimination (area-under-the-curve, AUCs), and calibration (index χ2). We also examined a composite unhealthy cardiovascular profile score summarizing glucose, lipids, and blood pressure. RESULTS: No single obesity index consistently performed statistically significantly better than the others across the outcome models. Based on point estimates, WHtR trended towards best performance in classifying diabetes (PR = 1.58 [1.45-1.72], AUC = 0.77, men; PR = 1.59 [1.47-1.71], AUC = 0.80, women) and hypertension (PR = 1.34 [1.26,1.42], AUC = 0.70, men; PR = 1.41 [1.33,1.50], AUC = 0.78, women). WC (mean difference = 0.24 SD [0.21-0.27]) and WHtR (mean difference = 0.24 SD [0.21,0.28]) had the strongest associations with the composite unhealthy cardiovascular profile score in women but not in men. CONCLUSIONS: WC and WHtR were the most useful indices for identifying South Asian adults with prevalent diabetes and hypertension. Collection of waist circumference data in South Asian health surveys will be informative for population-based CVD surveillance efforts.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:CARRS, CVD,
Subjects:Diabetes Epidemiology
Diabetology > Cardiovascular Diabetology
Divisions:Department of Epidemiology
Department of Diabetology
ID Code:1035
Deposited By:surendar radha
Deposited On:17 Jun 2017 15:44
Last Modified:17 Jun 2017 15:44

Repository Staff Only: item control page