Genetics of gestational diabetes mellitus

Radha, V and Kanthimathi, S and Anjana, R M and Mohan, V (2016) Genetics of gestational diabetes mellitus. Journal Of Pakistan Medical Association . s11.



Gestational diabetes mellitus (GDM) has now become a major public health problem because of its prevalence and its associated complications during pregnancy. Earlier studies have suggested that type 2 diabetes mellitus (T2DM) and GDM might have similar pathophysiology,such as increased insulin resistance, decreased insulin secretion resulting in hyperglycaemia. Evidence for a genetic basis of GDM has been poorly understood. To some extent, the current advancement in genomic techniques has thrown better light on the genetics of GDM. Based on the candidate gene approach and genome wide association studies, genetic loci in several genes that are responsible for insulin secretion, insulin resistance, lipid and glucose metabolism and other pathways have shown association with the GDM susceptibility. Understanding the possible underlying genetic factors of GDM would help us in gaining knowledge on the pathophysiologic mechanism of the disease.

Item Type:Article
Official URL/DOI:
Uncontrolled Keywords:GDM, CDKAL1, HKDC1, HMG20A, HNF4A
Subjects:Genetics and Diabetes
Divisions:Department of Advanced Research Biochemistry
ID Code:1017
Deposited By:surendar radha
Deposited On:23 Dec 2016 12:21
Last Modified:23 Dec 2016 12:21

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