Hexokinase Domain Containing 1 (HKDC1) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population

Kanthimathi, S and Liju, S and Laasya, D and Anjana, R M and Mohan, V and Radha, V (2016) Hexokinase Domain Containing 1 (HKDC1) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population. Annals of Human Genetics, 80 (4). p. 241. ISSN 00034800

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Abstract

Hexokinase domain containing 1 (HKDC1), a novel human hexokinase gene, is known to affect glucose metabolism and was shown to have a strong association with 2-h plasma glucose in pregnant women in a recent genome wide association study. This study aimed to evaluate the association of these regulatory variants of HKDC1 (rs1076224, rs4746822, rs2394529 and rs9645501) with gestational diabetes mellitus (GDM) in a South Indian population. The regulatory variants of HKDC1 were genotyped in unrelated 500 women with GDM and 510 non-GDM individuals by using the MassARRAY system and by direct DNA sequencing. The minor alleles of the HKDC1 gene regulatory variants, namely rs10762264 and rs4746822, showed a significant association with GDM and these alleles conferred as much as 1.24 and 1.34 times higher risk for GDM, respectively. This is the first study to demonstrate the association of HKDC1 genetic variants with susceptibility to GDM.

Item Type:Article
Official URL/DOI:http://dx.doi.org/10.1111/ahg.12155
Uncontrolled Keywords:gestational diabetes mellitus, glucose homeostasis, hexokinase, HKDC1, 2-h plasma glucose, South Indian
Subjects:Genetics and Diabetes > Maturity-Onset Diabetes of the Young(MODY)
Genetics and Diabetes
Divisions:Department of Advanced Research Biochemistry
ID Code:1000
Deposited By:surendar radha
Deposited On:28 Jun 2016 17:14
Last Modified:28 Jun 2016 17:14

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