Evolution of Sulfonylureas: Commentary on Developmental Process and Initial Trials

Abstract

In the last few decades, the options of pharmacotherapies for the management of patients with type 2 diabetes mellitus (T2DM) have increased dramatically. Among them, the sulfonylureas (SUs) are one of the oldest and most commonly used antihyperglycemic agents for the treatment of T2DM.The use of SUs in the treatment armamentarium of diabetes mellitus has evolved, over past few decades. Sulfonylureas have emerged from being a mere antihyperglycemic agent to frontrunners in the field of precision medicine. Here we will discuss developmental process of SUs, the initial trials of SUs and the place of SUs in the precision diabetes medicine.